Itga2tm1Ztr
Targeted Allele Detail
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Symbol: |
Itga2tm1Ztr |
Name: |
integrin alpha 2; targeted mutation 1, Mary M Zutter |
MGI ID: |
MGI:2183401 |
Synonyms: |
alpha2- |
Gene: |
Itga2 Location: Chr13:114969617-115068588 bp, - strand Genetic Position: Chr13, 64.61 cM
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Alliance: |
Itga2tm1Ztr page
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 1 was flanked by an upstream floxed neo cassette and a loxP site inserted into intron 1. Transient transfection of ES cells with cre recombinase expression plasmids resulted in the excision of the neo cassette and exon 1. Flow cytometric analysis of platelets obtained from homozygous mutant mice showed an absence of surface expression. Western blot analysis of protein lysates from platelets and mammary glands confirmed the lack of protien. Neither full-length nor truncated transcript was detected by RT-PCR analysis of mammary gland lysates.
(J:77798)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Itga2 Mutation: |
80 strains or lines available
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Original: |
J:77798 Chen J, et al., The alpha(2) integrin subunit-deficient mouse: a multifaceted phenotype including defects of branching morphogenesis and hemostasis. Am J Pathol. 2002 Jul;161(1):337-44 |
All: |
17 reference(s) |
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