Nectin2^tm1Vrr
Targeted Allele Detail

Summary

• Symbol: Nectin2^tm1Vrr
• Name: nectin cell adhesion molecule 2; targeted mutation 1, Vincent R Racaniello
• MGI ID: MGI:2183405
• Synonyms: nectin-2^-
• Gene: Nectin2 Location: Chr7:19450569-19483498 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Nectin2^tm1Vrr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61334
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3' portion of exon 3 was replaced with a neomycin selection cassette. Flow cytometric analysis of primary cultures of kidney cells derived from homozygous mutant mice showed an absence of protein surface expression. (J:61334)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nectin2 Mutation: 80 strains or lines available

References

• Original: J:61334 Bouchard MJ, et al., Defects in nuclear and cytoskeletal morphology and mitochondrial localization in spermatozoa of mice lacking nectin-2, a component of cell-cell adherens junctions. Mol Cell Biol. 2000 Apr;20(8):2865-73
• All: 1 reference(s)