Vdr^tm1Gcm
Targeted Allele Detail

Summary

• Symbol: Vdr^tm1Gcm
• Name: vitamin D (1,25-dihydroxyvitamin D3) receptor; targeted mutation 1, Geert Carmeliet
• MGI ID: MGI:2183407
• Synonyms: Leuven^lox, VDR^lox
• Gene: Vdr Location: Chr15:97752308-97806177 bp, - strand Genetic Position: Chr15, 53.85 cM
• Alliance: Vdr^tm1Gcm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72578
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo-cassette was inserted upstream of exon 2 and a third loxP site was introduced downstream of exon 2 via homologous recombination. Transient expression of cre recombinase in correctly targeted cells facilitated the removal of the neo cassette and was confirmed by Southern blot analysis. (J:72578)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vdr Mutation: 36 strains or lines available

References

• Original: J:72578 Van Cromphaut SJ, et al., Duodenal calcium absorption in vitamin D receptor-knockout mice: functional and molecular aspects. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13324-9
• All: 29 reference(s)