Olig2^{tm1(cre/Esr1*)Htak}
Targeted Allele Detail

Summary

• Symbol: Olig2^{tm1(cre/Esr1*)Htak}
• Name: oligodendrocyte transcription factor 2; targeted mutation 1, Hirohide Takebayashi
• MGI ID: MGI:2183410
• Synonyms: Olig2^-, Olig2-CreER, Olig2^KICreER, Olig2^{tm1(cre/Esr1)Htak}, Olig2^{tm1(cre/Esr1)Yin}
• Gene: Olig2 Location: Chr16:91022345-91025565 bp, + strand Genetic Position: Chr16, 52.6 cM
• Alliance: Olig2^{tm1(cre/Esr1*)Htak} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77821
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Olig2^{tm1(cre/Esr1*)Htak} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Olig2 (MGI:1355331)

• Mutation details: The portion of exon 2 encoding the basic helix-loop-helix domain was replaced with a cassette containing neo and tamoxifen-inducible cre genes. The expression of the inducible cre gene was driven by the endogenous promoter. (J:77821)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Olig2 (mouse) Summary of all recombinase alleles driven by Olig2. Alliance mouse Olig2 gene page

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Olig2 Mutation: 46 strains or lines available

References

• Original: J:77821 Takebayashi H, et al., The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages. Curr Biol. 2002 Jul 9;12(13):1157-63
• All: 32 reference(s)