Alppl2^tm1Jlm
Targeted Allele Detail

Summary

• Symbol: Alppl2^tm1Jlm
• Name: alkaline phosphatase, placental-like 2; targeted mutation 1, Jose Luis Millan
• MGI ID: MGI:2183412
• Synonyms: EAP-, EAP.ko
• Gene: Alppl2 Location: Chr1:87014416-87017650 bp, - strand Genetic Position: Chr1, 44.05 cM, cytoband C5
• Alliance: Alppl2^tm1Jlm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39015
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 5, exon 6, exon 7, and part of exon 8, were replaced with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot and RT-PCR analysis. (J:39015)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Alppl2 Mutation: 26 strains or lines available

References

• Original: J:39015 Narisawa S, et al., Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia. Dev Dyn. 1997 Mar;208(3):432-46
• All: 3 reference(s)