Ate1^tm1Avar
Targeted Allele Detail

Summary

• Symbol: Ate1^tm1Avar
• Name: arginyltransferase 1; targeted mutation 1, Alexander Varshavsky
• MGI ID: MGI:2183428
• Synonyms: ATE1-, ATE1^nlsLacZ
• Gene: Ate1 Location: Chr7:129993223-130122099 bp, - strand Genetic Position: Chr7, 73.19 cM
• Alliance: Ate1^tm1Avar page

Small and lean phenotype of Ate1^tm1Avar/Ate1^tm2.1Avar Tg(CAG-cre/Esr1*)5Amc/0 mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77750
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 1-3 with a lacZ-PGK-neo derived cassette via homologous recombination. Absence of gene expression in homozygous mutant E13.5 embryos was demonstrated by Nothern blot analysis using a probe complementary to the deleted region. (J:77750)

Expression

In Mice Carrying this Mutation:	122 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ate1 Mutation: 43 strains or lines available

References

• Original: J:77750 Kwon YT, et al., An essential role of N-terminal arginylation in cardiovascular development. Science. 2002 Jul 5;297(5578):96-9
• All: 9 reference(s)