Kcnj6^tm1Stf
Targeted Allele Detail

Summary

• Symbol: Kcnj6^tm1Stf
• Name: potassium inwardly-rectifying channel, subfamily J, member 6; targeted mutation 1, Markus Stoffel
• MGI ID: MGI:2183429
• Synonyms: GIRK2-
• Gene: Kcnj6 Location: Chr16:94549495-94798560 bp, - strand Genetic Position: Chr16, 55.44 cM
• Alliance: Kcnj6^tm1Stf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38206
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 2. While normal transcript was absent, truncated message was detected in homozygous mutant mice via RT-PCR analysis. Neither normal protein nor protein encoded by the truncated transcript was detected by Western blot analysis, using antibodies directed against the amino and carboxy termini. (J:38206)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnj6 Mutation: 26 strains or lines available

References

• Original: J:38206 Signorini S, et al., Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2. Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):923-7
• All: 42 reference(s)