Kcnj2^tm1Swz
Targeted Allele Detail

Summary

• Symbol: Kcnj2^tm1Swz
• Name: potassium inwardly-rectifying channel, subfamily J, member 2; targeted mutation 1, Thomas L Schwarz
• MGI ID: MGI:2183430
• Synonyms: Kir2.1^-
• Gene: Kcnj2 Location: Chr11:110956990-110967647 bp, + strand Genetic Position: Chr11, 75.23 cM
• Alliance: Kcnj2^tm1Swz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78077
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire open reading frame of the endogenous gene was replaced with a neomycin selection cassette. (J:78077)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Kcnj2 Mutation: 30 strains or lines available

References

• Original: J:78077 Zaritsky JJ, et al., Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation. Circ Res. 2000 Jul 21;87(2):160-6
• All: 6 reference(s)