Pcdh15^av-5J
Chemically induced Allele Detail

Summary

• Symbol: Pcdh15^av-5J
• Name: protocadherin 15; Ames Waltzer 5 Jackson
• MGI ID: MGI:2183469
• Synonyms: neuroscience mutagenesis facility, 19, nmf19, NMF19, Pcdh15^av-nmf19, Pcdh15^nmf19
• Gene: Pcdh15 Location: Chr10:72935174-74485569 bp, + strand Genetic Position: Chr10, 37.43 cM
• Alliance: Pcdh15^av-5J page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Modified isoform(s))
• Mutation: Single point mutation
• Mutation details: RT-PCR and sequencing demonstrated that the coding sequence of exon 13 was spliced to exon 15 due to an A to G substitution of the splice donor sequence of exon 14, yet immunohistochemistry with an antibody to the cytoplasmic domain encoded by exons 32-34 found normal expression patterns in the mouse retina and cDNA from retina and inner ear identified a novel isoform that excludes exons 3 through 15 and includes 6 extracellular domains, the transmembrane and cytoplasmic domains. (J:97048, J:112247)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pcdh15 Mutation: 135 strains or lines available

References

• Original: J:78134 JAX Neuroscience Mutagenesis Facility, Heritable mouse mutants from JAX NMF ENU Mutagenesis Program. MGI Direct Data Submission. 2002
• All: 4 reference(s)