Fanca^tm1Faw
Targeted Allele Detail

Summary

• Symbol: Fanca^tm1Faw
• Name: Fanconi anemia, complementation group A; targeted mutation 1, Fre Arwert
• MGI ID: MGI:2183470
• Synonyms: Fanca-
• Gene: Fanca Location: Chr8:123995039-124045315 bp, - strand Genetic Position: Chr8, 72.1 cM
• Alliance: Fanca^tm1Faw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63742
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 through 7 were deleted by the insertion of a cassette comprised of a splice acceptor site, IRES-lacZ, and neo. Protein was undetected in homozygous mutant mice via Western blot analysis of splenic tissue. (J:63742)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fanca^tm1Faw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fanca Mutation: 81 strains or lines available

References

• Original: J:63742 Cheng NC, et al., Mice with a targeted disruption of the fanconi anemia homolog fanca. Hum Mol Genet. 2000 Jul 22;9(12):1805-11
• All: 20 reference(s)