Fancg^tm1Faw
Targeted Allele Detail

Summary

• Symbol: Fancg^tm1Faw
• Name: Fanconi anemia, complementation group G; targeted mutation 1, Fre Arwert
• MGI ID: MGI:2183473
• Synonyms: Fancg-
• Gene: Fancg Location: Chr4:43002343-43010506 bp, - strand Genetic Position: Chr4, 22.97 cM, cytoband B1
• Alliance: Fancg^tm1Faw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74737
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced exons 1 through 4. Western blot analysis of splenic lysates and mouse embyronic fibroblasts confirmed the absence of protein in homozygous mutant mice. (J:74737)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fancg^tm1Faw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fancg Mutation: 37 strains or lines available

References

• Original: J:74737 Koomen M, et al., Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice. Hum Mol Genet. 2002 Feb 1;11(3):273-81
• All: 9 reference(s)