Gcm1^tm1Jcc
Targeted Allele Detail

Summary

• Symbol: Gcm1^tm1Jcc
• Name: glial cells missing homolog 1; targeted mutation 1, James C Cross
• MGI ID: MGI:2183479
• Synonyms: Gcm1^-
• Gene: Gcm1 Location: Chr9:77959240-77972906 bp, + strand Genetic Position: Chr9, 43.49 cM, cytoband E1-E3
• Alliance: Gcm1^tm1Jcc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63123
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence upstream of the start codon in exon 2 through intron 5 was replaced with a cassette containing lacZ and neo. (J:63123)

Expression

In Mice Carrying this Mutation:	27 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gcm1 Mutation: 23 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Preeclampsia/Eclampsia (induced by fetus J:185528)

References

• Original: J:63123 Anson-Cartwright L, et al., The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta. Nat Genet. 2000 Jul;25(3):311-4
• All: 6 reference(s)