Mdm4tm1Glo
Targeted Allele Detail
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Symbol: |
Mdm4tm1Glo |
Name: |
transformed mouse 3T3 cell double minute 4; targeted mutation 1, Guillermina Lozano |
MGI ID: |
MGI:2183485 |
Synonyms: |
Mdm4- |
Gene: |
Mdm4 Location: Chr1:132913843-132958325 bp, - strand Genetic Position: Chr1, 57.75 cM, cytoband G-G
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Alliance: |
Mdm4tm1Glo page
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Germline Transmission: |
Earliest citation of germline transmission:
J:71532
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 3 through 5 were replaced with a neomycin selection cassette. The deleted region encoded the majority of the Trp53-binding domain (amino acids 27-96). Aberrant splicing around the neo transgene would result in a frameshift mutation. Protein was undetected in homozygous mutant mice by Western blot analysis.
(J:71532)
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View phenotypes and curated references for all genotypes (concatenated display).
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List all tumor models in MMHCdb carrying
Mdm4tm1Glo
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Mdm4 Mutation: |
193 strains or lines available
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Original: |
J:71532 Parant J, et al., Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet. 2001 Sep;29(1):92-5 |
All: |
17 reference(s) |
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