Tgfbr2^tm1.1Karl
Targeted Allele Detail

Summary

• Symbol: Tgfbr2^tm1.1Karl
• Name: transforming growth factor, beta receptor II; targeted mutation 1.1, Stefan Karlsson
• MGI ID: MGI:2183504
• Synonyms: T-Beta-RII^-
• Gene: Tgfbr2 Location: Chr9:115916763-116004431 bp, - strand Genetic Position: Chr9, 68.39 cM
• Alliance: Tgfbr2^tm1.1Karl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77844
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A floxed genomic fragment encompassing exon 4 and a neo cassette was deleted via cre-mediated recombination in ES cells. A single loxP site was left upstream of exon 5. (J:77844)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfbr2 Mutation: 40 strains or lines available

References

• Original: J:77844 Leveen P, et al., Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable. Blood. 2002 Jul 15;100(2):560-8
• All: 3 reference(s)