Tg(Otog-cre)1Ugds
Transgene Detail

Summary

• Symbol: Tg(Otog-cre)1Ugds
• Name: transgene insertion 1, Unite de Genetique des Deficits Sensoriels
• MGI ID: MGI:2183511
• Synonyms: Otog-cre, Tg(Otog-cre)1Ptt
• Transgene: Tg(Otog-cre)1Ugds Location: unknown
• Alliance: Tg(Otog-cre)1Ugds page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Otog-cre)1Ugds expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Otog (MGI:1202064)

• Mutation details: The transgenic construct was generated by inserting sequence encoding NLS-cre recombinase into a BAC encompassing the 5' portion of the murine Otog gene. Otog is endogenously expressed in the inner ear. Cre was flanked upstream by the Otog promoter and UTR of exon 1 and downstream by the coding region of exon 1 and all of exon 2. (J:77823)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Otog (mouse) Summary of all recombinase alleles driven by Otog. Alliance mouse Otog gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:77823 Cohen-Salmon M, et al., Targeted ablation of connexin26 in the inner ear epithelial gap junction network causes hearing impairment and cell death. Curr Biol. 2002 Jul 9;12(13):1106-11
• All: 3 reference(s)