Pth1r^tm3Hmk
Targeted Allele Detail

Summary

• Symbol: Pth1r^tm3Hmk
• Name: parathyroid hormone 1 receptor; targeted mutation 3, Henry M Kronenberg
• MGI ID: MGI:2183514
• Synonyms: Pthr^d/d
• Gene: Pth1r Location: Chr9:110551153-110576213 bp, - strand Genetic Position: Chr9, 60.56 cM, cytoband F
• Alliance: Pth1r^tm3Hmk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77683
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: This hypomorphic allele was identified in conjunction with Pthr^tm2Hmk. Southern blot analyses showed three copies of the targeting vector, containing a floxed exon 1, at the endogenous locus. Levels of transcript were determined to be reduced in homozygous mutant mice via in situ hybridization of the growth plate and Northern blot analysis of total renal RNA. (J:77683)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pth1r Mutation: 29 strains or lines available

References

• Original: J:77683 Kobayashi T, et al., PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps. Development. 2002 Jun;129(12):2977-86
• All: 2 reference(s)