Gapdh^m2Neu
Radiation induced Allele Detail

Summary

• Symbol: Gapdh^m2Neu
• Name: glyceraldehyde-3-phosphate dehydrogenase; mutation 2, Neuherberg
• MGI ID: MGI:2183516
• Synonyms: GAPDH 577
• Gene: Gapdh Location: Chr6:125138812-125143450 bp, - strand Genetic Position: Chr6, 59.32 cM, cytoband C
• Alliance: Gapdh^m2Neu page

Mutation origin

• Strain of Origin: (101/El x C3H/El)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Intragenic deletion
• Mutation details: An X-ray induced mutation that was shown to express 45% of normal levels of the encoded enzyme in heterozygous mice. Fifty-five nucleotides at the end of intron 1-2 as well as 36 nucleotides at the beginning of exon 2 (positions 24-59) are deleted. This deletion prevents correct splicing and consequently all of exon 2 is lost. (J:126359)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gapdh Mutation: 41 strains or lines available

References

• Original: J:15476 Charles DJ, et al., Enzyme-activity mutations detected in mice after paternal fractionated irradiation. Mutat Res. 1986 May;160(3):243-8
• All: 3 reference(s)