Hnf4a^tm1.1Gonz
Targeted Allele Detail

Summary

• Symbol: Hnf4a^tm1.1Gonz
• Name: hepatic nuclear factor 4, alpha; targeted mutation 1.1, Frank J Gonzalez
• MGI ID: MGI:2183520
• Synonyms: Hnf4a^loxP, HNF4-alpha^fl, HNF4-alpha^flox, HNF4alpha-flox, HNF4alpha^flox, hnf4^fl
• Gene: Hnf4a Location: Chr2:163348731-163414827 bp, + strand Genetic Position: Chr2, 84.32 cM
• Alliance: Hnf4a^tm1.1Gonz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67396
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This allele was generated by breeding mice carrying Hnf4^tm1Gonz with transgenic mice expressing cre recombinase via the EIIa promoter. Expression of cre resulted in the excision of the floxed neomycin cassette, leaving a floxed region containing exons 4 and 5. Hnf4^tm1.2Gonz was simultaneously generated by the same strategy. (J:67396)

Disease models

Expression

In Mice Carrying this Mutation:	73 assay results 7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hnf4a Mutation: 28 strains or lines available

References

• Original: J:67396 Hayhurst GP, et al., Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol. 2001 Feb;21(4):1393-403
• All: 72 reference(s)