Fgfr2^tm3Lni
Targeted Allele Detail

Summary

• Symbol: Fgfr2^tm3Lni
• Name: fibroblast growth factor receptor 2; targeted mutation 3, Peter Lonai
• MGI ID: MGI:2183528
• Gene: Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
• Alliance: Fgfr2^tm3Lni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77698
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A stop codon was introduced into exon 9 and a floxed neomycin cassette was introduced into intron 9 via homologous recombination. Exon 9 is an Fgfr2IIIc-specific exon of the gene. (J:77698)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr2 Mutation: 90 strains or lines available

References

• Original: J:77698 Eswarakumar VP, et al., The IIIc alternative of Fgfr2 is a positive regulator of bone formation. Development. 2002 Aug 15;129(16):3783-93
• All: 3 reference(s)