Fgfr2^tm3.1Lni
Targeted Allele Detail

Summary

• Symbol: Fgfr2^tm3.1Lni
• Name: fibroblast growth factor receptor 2; targeted mutation 3.1, Peter Lonai
• MGI ID: MGI:2183529
• Synonyms: Fgfr2IIIc^-
• Gene: Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
• Alliance: Fgfr2^tm3.1Lni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77698
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeted mutation is derived from Fgfr2^tm3Lni by crossing to a cre-expressing line to remove the floxed neomycin cassette from intron 9. The engineered stop codon in exon 9 was left intact. The FgfrIIIc-specific absence of gene expression in homozygous mutant animals was verified by in situ hybridization. (J:77698)

Expression

In Mice Carrying this Mutation:	39 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr2 Mutation: 90 strains or lines available

References

• Original: J:77698 Eswarakumar VP, et al., The IIIc alternative of Fgfr2 is a positive regulator of bone formation. Development. 2002 Aug 15;129(16):3783-93
• All: 9 reference(s)