Ncoa1^tm1Bwo
Targeted Allele Detail

Summary

• Symbol: Ncoa1^tm1Bwo
• Name: nuclear receptor coactivator 1; targeted mutation 1, Bert W O'Malley
• MGI ID: MGI:2183532
• Synonyms: SRC-1-, SRC-1 KO
• Gene: Ncoa1 Location: Chr12:4297362-4527182 bp, - strand Genetic Position: Chr12, 2.05 cM, cytoband A2-A3
• Alliance: Ncoa1^tm1Bwo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46528
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The insertion of a vector containing a GLVP cassette and a neomycin resistance gene changed an internal ATG codon (methionine 381) to a stop codon and deleted 9kb of sequence. The deleted region encoded all of the functional domains except for the bHLH-PAS domain. Western blotting of renal and hepatic protein extracts showed the absence of full-length protein in homozygous mutant mice. (J:46528)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncoa1 Mutation: 169 strains or lines available

References

• Original: J:46528 Xu J, et al., Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene. Science. 1998 Mar 20;279(5358):1922-5
• All: 45 reference(s)