Frk^tm1Liu
Targeted Allele Detail

Summary

• Symbol: Frk^tm1Liu
• Name: fyn-related kinase; targeted mutation 1, Edison T Liu
• MGI ID: MGI:2183538
• Synonyms: FRK^-, frk/rak^-
• Gene: Frk Location: Chr10:34359395-34487274 bp, + strand Genetic Position: Chr10, 18.85 cM
• Alliance: Frk^tm1Liu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77207
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1a and 1b were replaced with a neomycin selection cassette. The deleted region contained the 5' untranslated region, the start codon, and sequence encoding the amino terminal residues and the SH2 and SH3 domains. No transcript was detected by Northern blot anlysis of homozygous mutant mice. Western blot analysis confirmed the absence of protein. (J:77207)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Frk Mutation: 32 strains or lines available

References

• Original: J:77207 Chandrasekharan S, et al., Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak. Mol Cell Biol. 2002 Jul;22(14):5235-47
• All: 3 reference(s)