Agt^tm1Ii
Targeted Allele Detail

Summary

• Symbol: Agt^tm1Ii
• Name: angiotensinogen; targeted mutation 1, Iekuni Ichikawa
• MGI ID: MGI:2183545
• Synonyms: Agt-, Angt-KO
• Gene: Agt Location: Chr8:125283326-125296445 bp, - strand Genetic Position: Chr8, 72.81 cM
• Alliance: Agt^tm1Ii page

Abnormal kidney morphology in 3 week old Agt^tm1Ii/Agt^tm1Ii mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30061
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.5 kb region of the gene containing exon 2 was replaced with a PGK-neo cassette via homologous recombination. Exon 2 encodes the translation start site and the entire octapeptide region of the protein. Absence of gene expression was confirmed in homozygous mutant animals by Northern blot analysis of liver tissue. Furthermore, no plasma angiotensinogen could be detected in homozygous mutant animals. (J:30061)

Expression

In Structures Affected by this Mutation:

17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agt Mutation: 35 strains or lines available

References

• Original: J:30061 Niimura F, et al., Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J Clin Invest. 1995 Dec;96(6):2947-54
• All: 6 reference(s)