Clec10a^tm1Hed
Targeted Allele Detail

Summary

• Symbol: Clec10a^tm1Hed
• Name: C-type lectin domain family 10, member A; targeted mutation 1, Stephen M Hedrick
• MGI ID: MGI:2183546
• Synonyms: mMGL^-
• Gene: Clec10a Location: Chr11:70057449-70061662 bp, + strand Genetic Position: Chr11, 42.99 cM
• Alliance: Clec10a^tm1Hed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78035
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a neomycin selection cassette. No transcript was detected in homozygous mutant mice via Northern blot and RT-PCR analyses, however, immunohistochemical staining showed low levels of reactivity in peritoneal exudate cells. (J:78035)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Clec10a Mutation: 23 strains or lines available

References

• Original: J:78035 Onami TM, et al., Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins. Mol Cell Biol. 2002 Jul;22(14):5173-81
• All: 14 reference(s)