Wt1^tm1.1Jak
Targeted Allele Detail

Summary

• Symbol: Wt1^tm1.1Jak
• Name: WT1 transcription factor; targeted mutation 1.1 Jordan A Kreidberg
• MGI ID: MGI:2183548
• Synonyms: Wt1^ex5c, Wt1^ex5cre
• Gene: Wt1 Location: Chr2:104956874-105003959 bp, + strand Genetic Position: Chr2, 55.06 cM, cytoband E
• Alliance: Wt1^tm1.1Jak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76780
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The neomycin cassette was removed from the Wt1^tm1Jak allele via cre mediated recombination to create the Wt^tm1.1Jak allele. This resulted in the deletion of the mammalian specific alternatively spliced exon 5, which encodes a 17 amino acid sequence known to interact with the transcription factor Pawr. (J:76780)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wt1 Mutation: 34 strains or lines available

References

• Original: J:76780 Natoli TA, et al., A mammal-specific exon of WT1 is not required for development or fertility. Mol Cell Biol. 2002 Jun;22(12):4433-8
• All: 1 reference(s)