Gfra3^tm1Jmi
Targeted Allele Detail

Summary

• Symbol: Gfra3^tm1Jmi
• Name: glial cell line derived neurotrophic factor family receptor alpha 3; targeted mutation 1, Jeffrey Milbrandt
• MGI ID: MGI:2183558
• Synonyms: GFRalpha3^tlacZ
• Gene: Gfra3 Location: Chr18:34822951-34853440 bp, - strand Genetic Position: Chr18, 18.69 cM
• Alliance: Gfra3^tm1Jmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78008
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The endogenous locus was disrupted by the insertion of a tau-lacZ cassette at the start codon by homologous recombination. A floxed neo cassette that was included in the targeting vector was excised via in vivo cre mediated recombination, leaving a single loxP site immediately downstream of the tau-lacZ sequence. Normal transcript was undetected by RT-PCR analysis of homozygous mutant mice. (J:78008)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gfra3 Mutation: 33 strains or lines available

References

• Original: J:78008 Honma Y, et al., Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons. Neuron. 2002 Jul 18;35(2):267-82
• All: 3 reference(s)