Nhlh1^tm1Irk
Targeted Allele Detail

Summary

• Symbol: Nhlh1^tm1Irk
• Name: nescient helix loop helix 1; targeted mutation 1, Ilan R Kirsch
• MGI ID: MGI:2183573
• Synonyms: Nhlh1^-
• Gene: Nhlh1 Location: Chr1:171879859-171885140 bp, - strand Genetic Position: Chr1, 79.54 cM
• Alliance: Nhlh1^tm1Irk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78031
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding sequence, which is entirely contained in exons 1 and 2, was replaced with a neomycin selection cassette. Transcript was determined to be absent in homozygous mutant mice via Northern blot analysis. (J:78031)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nhlh1 Mutation: 17 strains or lines available

References

• Original: J:78031 Cogliati T, et al., Predisposition to arrhythmia and autonomic dysfunction in Nhlh1-deficient mice. Mol Cell Biol. 2002 Jul;22(14):4977-83
• All: 1 reference(s)