Tagln^tm1Msp
Targeted Allele Detail

Summary

• Symbol: Tagln^tm1Msp
• Name: transgelin; targeted mutation 1, Michael S Parmacek
• MGI ID: MGI:2183575
• Synonyms: SM22-, SM22alpha-LacZ, SM22alpha^-LacZ
• Gene: Tagln Location: Chr9:45840926-45847356 bp, - strand Genetic Position: Chr9, 25.36 cM
• Alliance: Tagln^tm1Msp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67387
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, intron 2, exon 3, and part of intron 3 were replaced with an in-frame lacZ gene inserted at the initiation codon followed by a neomycin selection cassette. Northern and western blot analysis demonstrated that no detectable wild-type transcript or protein was expressed from this allele. Histochemical analysis demonstrated that beta-galactosidase was expressed from this allele under the control of the endogenous promoter. (J:67387)

Expression

In Mice Carrying this Mutation:

23 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tagln Mutation: 28 strains or lines available

Notes

ES cell line = RW.

References

• Original: J:67387 Zhang JC, et al., Analysis of SM22alpha-deficient mice reveals unanticipated insights into smooth muscle cell differentiation and function. Mol Cell Biol. 2001 Feb;21(4):1336-44
• All: 11 reference(s)