Agrp^tm1Sqn
Targeted Allele Detail

Summary

• Symbol: Agrp^tm1Sqn
• Name: agouti related neuropeptide; targeted mutation 1, Su Qian
• MGI ID: MGI:2183577
• Synonyms: Agrp^-
• Gene: Agrp Location: Chr8:106293327-106306477 bp, - strand Genetic Position: Chr8, 53.04 cM, cytoband D1-D2
• Alliance: Agrp^tm1Sqn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78034
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with a neomycin selection cassette. Transcript was undetected in homozygous mutant mice via in situ hybridization. (J:78034)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Agrp Mutation: 17 strains or lines available

References

• Original: J:78034 Qian S, et al., Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Mol Cell Biol. 2002 Jul;22(14):5027-35
• All: 14 reference(s)