Mc3r^tm1Lvp
Targeted Allele Detail

Summary

• Symbol: Mc3r^tm1Lvp
• Name: melanocortin 3 receptor; targeted mutation 1, Lex H T Van der Ploeg
• MGI ID: MGI:2183582
• Synonyms: MC3^-, Mc3r^-
• Gene: Mc3r Location: Chr2:172090412-172093034 bp, + strand Genetic Position: Chr2, 94.8 cM
• Alliance: Mc3r^tm1Lvp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64365
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with a neomycin selection cassette. Transcript was identified to be absent in the brains of homozygous mutant mice via in situ hybridization. (J:64365)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mc3r Mutation: 31 strains or lines available

References

• Original: J:64365 Chen AS, et al., Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet. 2000 Sep;26(1):97-102
• All: 9 reference(s)