Mc4r^tm1Dhu
Targeted Allele Detail

Summary

• Symbol: Mc4r^tm1Dhu
• Name: melanocortin 4 receptor; targeted mutation 1, Dennis Huszar
• MGI ID: MGI:2183586
• Synonyms: MC4r-, MC-4R(-), MC4r-KO
• Gene: Mc4r Location: Chr18:66990776-66993558 bp, - strand Genetic Position: Chr18, 39.72 cM, cytoband E1
• Alliance: Mc4r^tm1Dhu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38224
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced all but the first 20 nucleotides of the coding region. Northern blot analysis showed a lack of transcript in homozygous mice. (J:38224)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mc4r Mutation: 48 strains or lines available

References

• Original: J:38224 Huszar D, et al., Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 1997 Jan 10;88(1):131-41
• All: 61 reference(s)