Prkar1a^tm1Gsm
Targeted Allele Detail

Summary

• Symbol: Prkar1a^tm1Gsm
• Name: protein kinase, cAMP dependent regulatory, type I, alpha; targeted mutation 1, G Stanley McKnight
• MGI ID: MGI:2183602
• Gene: Prkar1a Location: Chr11:109540231-109560482 bp, + strand Genetic Position: Chr11, 72.33 cM
• Alliance: Prkar1a^tm1Gsm page

Tumors in Prkar1a^tm1Gsm/Prkar1a⁺ mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78010
• Parent Cell Line: REK2 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 3 was disrupted by the insertion of a neomycin selection cassette. The absence of endcoded protein in homozygous mutant mice was confirmed via Western blot analysis. (J:78010)

Disease models

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkar1a Mutation: 19 strains or lines available

References

• Original: J:78010 Amieux PS, et al., Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo. J Biol Chem. 2002 Jul 26;277(30):27294-304
• All: 6 reference(s)