Mapk7^tm1Kda
Targeted Allele Detail

Summary

• Symbol: Mapk7^tm1Kda
• Name: mitogen-activated protein kinase 7; targeted mutation 1, Keisuke Kuida
• MGI ID: MGI:2183604
• Synonyms: erk5-
• Gene: Mapk7 Location: Chr11:61379638-61385101 bp, - strand Genetic Position: Chr11, 37.96 cM
• Alliance: Mapk7^tm1Kda page

Mapk7^tm1Kda/Mapk7^tm1Kda embryos display multiple defects in cardiac development

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77725
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Portions of exons 2 and 3 were replaced with a neomycin selection cassette. Western blot analysis showed an absence of encoded protien in embryonic fibroblasts derived from homozygous mutant mice. (J:77725)

Expression

In Mice Carrying this Mutation:	27 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk7 Mutation: 32 strains or lines available

References

• Original: J:77725 Regan CP, et al., Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects. Proc Natl Acad Sci U S A. 2002 Jul 9;99(14):9248-53
• All: 2 reference(s)