Icmt^tm1Hzo
Targeted Allele Detail

Summary

• Symbol: Icmt^tm1Hzo
• Name: isoprenylcysteine carboxyl methyltransferase; targeted mutation 1, Huda Y Zoghbi
• MGI ID: MGI:2183607
• Synonyms: pccmt^-
• Gene: Icmt Location: Chr4:152381684-152391578 bp, + strand Genetic Position: Chr4, 83.02 cM
• Alliance: Icmt^tm1Hzo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77742
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A floxed region containing exons 2 through 4 was excised via the in vitro expression of cre recombinase. The deleted sequence encoded amino acids 65 through 224. Northern blot analysis of heterozygous mice showed an approximately 50% reduction in transcript levels, whereas transcript was undetected in homozygous mutant embryos by RT-PCR analysis. (J:77742)

Expression

In Mice Carrying this Mutation:	13 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Icmt Mutation: 12 strains or lines available

References

• Original: J:77742 Lin X, et al., Prenylcysteine carboxylmethyltransferase is essential for the earliest stages of liver development in mice. Gastroenterology. 2002 Jul;123(1):345-51
• All: 1 reference(s)