Mxd3tm1Rne
Targeted Allele Detail
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| Symbol: |
Mxd3tm1Rne |
| Name: |
Max dimerization protein 3; targeted mutation 1, Robert N Eisenman |
| MGI ID: |
MGI:2183621 |
| Synonyms: |
mad3- |
| Gene: |
Mxd3 Location: Chr13:55472981-55477636 bp, - strand Genetic Position: Chr13, 29.8 cM
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| Alliance: |
Mxd3tm1Rne page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:77649
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| Parent Cell Line: |
AK7 (ES Cell)
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| Strain of Origin: |
129S4/SvJaeSor
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin selection cassette replaced a region spanning the start codon in exon 1 and 5.8kb of intronic sequence following exon 4. In addtion to the initial methionine, the deleted sequence encoded the Sin3-interacting domain, a conserved HGYAS motif, and the basic and helix-loop-helix regions of the bHLH leucine zipper. RT-PCR analysis and in situ hybridization confirmed the absence of transcript in homozygous mutant embryos.
(J:77649)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Mxd3 Mutation: |
11 strains or lines available
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| Original: |
J:77649 Queva C, et al., Targeted deletion of the S-phase-specific Myc antagonist Mad3 sensitizes neuronal and lymphoid cells to radiation-induced apoptosis. Mol Cell Biol. 2001 Feb;21(3):703-12 |
| All: |
1 reference(s) |
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Analysis Tools
