Ctbp1^tm1Sor
Targeted Allele Detail

Summary

• Symbol: Ctbp1^tm1Sor
• Name: C-terminal binding protein 1; targeted mutation 1, Philippe Soriano
• MGI ID: MGI:2183644
• Synonyms: Ctbp1^-
• Gene: Ctbp1 Location: Chr5:33405067-33432338 bp, - strand Genetic Position: Chr5, 17.52 cM, cytoband B1
• Alliance: Ctbp1^tm1Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77905
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding amino acids 55 through 102 was replaced with a floxed neomycin selection cassette. RT-PCR and sequence analyses showed that the disrupted exon was excised and the resultant splicing of the adjacent exons introduced a frameshift mutation. The absence of protein was verifed by Western blot analysis of lysates obtained from homozygous mutant embyros. (J:77905)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ctbp1 Mutation: 35 strains or lines available

References

• Original: J:77905 Hildebrand JD, et al., Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Mol Cell Biol. 2002 Aug;22(15):5296-307
• All: 5 reference(s)