Tg(APPV717I)1130Kha
Transgene Detail

Summary

• Symbol: Tg(APPV717I)1130Kha
• Name: transgene insertion 1130, Karen Hsiao Ashe
• MGI ID: MGI:2183645
• Synonyms: Tg1130H, Tg(APPV717I)1130HKahs, Tg(APPV717I)1130Kahs, Tg(APPV717I)1130Kha, Tg(HuAPP695.TRImyc)1130H
• Transgene: Tg(APPV717I)1130Kha Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: Tg(APPV717I)1130Kha page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(APPV717I)1130Kha expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

• Mutation details: Overexpression of human APP gene encoding APP695.TRImyc (V717I, V721A, and M722V with a 3'-myc tag). The construct contained the APP gene fused to the hamster prion protein promoter. APP expression was measured in brains of transgenic mice by quantitation of immunoblots. This transgenic line was estimated to contain ~74 copies of the transgene. Other lines generated using this construct varied in copy number and severity of phenoytpe. (J:29880)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:29880 Hsiao KK, et al., Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron. 1995 Nov;15(5):1203-18
• All: 6 reference(s)