Ctbp2^{Gt(ROSA61)Sor}
Gene trapped Allele Detail

Summary

• Symbol: Ctbp2^{Gt(ROSA61)Sor}
• Name: C-terminal binding protein 2; gene trap ROSA61, Philippe Soriano
• MGI ID: MGI:2183646
• Synonyms: Ctbp2^-, Ctbp2^{Gt(ROSA)61Sor}, Ctbp2^{Gt(ROSABetageo)61Sor}
• Gene: Ctbp2 Location: Chr7:132589292-132726083 bp, - strand Genetic Position: Chr7, 76.32 cM
• Alliance: Ctbp2^{Gt(ROSA61)Sor} page

Mutation origin

• Mutant Cell Line: ROSA61
• Germline Transmission: Earliest citation of germline transmission: J:77905
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: ROSABetageo*
• Mutation details: A retroviral gene trap vector containing a lacZ/neo fusion gene integrated downstream of an exon that is common to both isoforms. The absence of protein was verifed by Western blot analysis of lysates obtained from homozygous mutant embyros. (J:77905)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  FHCRC-GT-ROSA61	CG465912 ; (MGI Seq Detail)	5' RACE	Chr7:132683485-132725075 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  9 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	18 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ctbp2^{Gt(ROSA61)Sor}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ctbp2 Mutation: 574 strains or lines available

References

• Original: J:77905 Hildebrand JD, et al., Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Mol Cell Biol. 2002 Aug;22(15):5296-307
• All: 4 reference(s)