Tg(APPSWE)2123Kha
Transgene Detail
|
Symbol: |
Tg(APPSWE)2123Kha |
Name: |
transgene insertion 2123, Karen Hsiao Ashe |
MGI ID: |
MGI:2183650 |
Synonyms: |
Tg2123, Tg2123H, Tg(APPSWE)2123HKahs, Tg(APPSWE)2123Kahs, Tg(APP*Swe)2123Kha, Tg(APPSWE)2123Kha, Tg(HuAPP695.SWE)2123H |
Transgene: |
Tg(APPSWE)2123Kha Location: unknown
|
Alliance: |
Tg(APPSWE)2123Kha page
|
|
|
Transgene Type: |
|
Transgenic (Inserted expressed sequence) |
Mutation: |
|
Insertion
|
|
|
Tg(APPSWE)2123Kha expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
APP (351) |
|
|
|
|
|
Mutation details: Overexpression of the human APP gene encoding the APP695.SWE mutation (K670N and M671L). The construct contained the APP gene fused to the hamster prion protein promoter. APP expression was measured in brains of transgenic mice by quantitation of immunoblots. This transgenic line was estimated to contain ~31 copies of the transgene. Other lines generated using this construct varied in copy number and severity of phenoytpe.
(J:29880)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
Original: |
J:29880 Hsiao KK, et al., Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron. 1995 Nov;15(5):1203-18 |
All: |
5 reference(s) |
|