Rxrg^tm2Ysa
Targeted Allele Detail

Summary

• Symbol: Rxrg^tm2Ysa
• Name: retinoid X receptor gamma; targeted mutation 2, Yumiko Saga
• MGI ID: MGI:2183717
• Synonyms: TV-2
• Gene: Rxrg Location: Chr1:167425953-167467192 bp, + strand Genetic Position: Chr1, 74.99 cM
• Alliance: Rxrg^tm2Ysa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77613
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into the isoform-specific exon 2. By targeting exon 2, transcription of the isoform most prominent in brain tissue is ablated, while the isoform which is produced from a transcript in which exon 1b splices to exon 3, and is most abundant in skeletal muscle, is unaffected. (J:77613)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rxrg Mutation: 29 strains or lines available

References

• Original: J:77613 Saga Y, et al., Impaired extrapyramidal function caused by the targeted disruption of retinoid X receptor RXRgamma1 isoform. Genes Cells. 1999 Apr;4(4):219-28
• All: 1 reference(s)