Tg(SOD1*G93A)2Gur
Transgene Detail

Summary

• Symbol: Tg(SOD1*G93A)2Gur
• Name: transgene insertion 2, Mark E Gurney
• MGI ID: MGI:2183718
• Synonyms: G1, G1L, hMg-SOD1(G93A), Tg(SOD1)2Gur, Tg(SOD1-G93A)2Gur
• Transgene: Tg(SOD1*G93A)2Gur Location: unknown Genetic Position: Chr12, Syntenic
• Alliance: Tg(SOD1*G93A)2Gur page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(SOD1*G93A)2Gur expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOD1 (6647)

  Sod1	(MGI:98351)

• Mutation details: The transgene construct consists of a human SOD1 gene carrying a glycine to alanine substitution at position 93 (G93A). The G93A mutation does not alter the activity of the protein. Northern blot and Western blot confirmed the expression of the human transgene in transgenic animals. (J:32665, J:43332, J:43347)

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

This is the original high copy number line, G1, reported in J:32556. Subsequently, the Tg(SOD1*G93A)1Gur line, which has a 40% greater copy number was derived from the original founder G1 and reported in J:76718.

References

• Original: J:32665 Gurney ME, et al., Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation [see comments] [published erratum appears in Science 1995 Jul 14;269(5221):149]. Science. 1994 Jun 17;264(5166):1772-5
• All: 54 reference(s)