Tg(Sod1*G86R)M1Jwg
Transgene Detail

Summary

• Symbol: Tg(Sod1*G86R)M1Jwg
• Name: transgene insertion M1, Jon W Gordon
• MGI ID: MGI:2183736
• Synonyms: M1, Tg(Sod1*G85R)M1Jwg, Tg(Sod1-G86R)M1Jwg
• Transgene: Tg(Sod1*G86R)M1Jwg Location: unknown
• Alliance: Tg(Sod1*G86R)M1Jwg page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Sod1*G86R)M1Jwg expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Sod1 (MGI:98351)

• Mutation details: The entire mouse Sod1 gene with an engineered point mutation in exon 4 resulting in a glycine to arginine substitution at residue 86 (G86R) was used as the transgene. Mutation G86R corresponds to the SOD1 G86R mutation found in some cases of human amyotrophic lateral sclerosis (ALS) patients. RT-PCR analysis detected expression of the transgene in brain, spinal cord, and other tissues. The missense mutation is a point mutation in exon 4 resulting in a glycine-86 to arginine substitution, which corresponds to amino acid position 86 in the human SOD1 protein. Transgenics exhibit widespread high expression of the transgene and do not exhibit diminished SOD1 activity. . (J:22628)

Disease models

Expression

In Structures Affected by this Mutation:

18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:22628 Ripps ME, et al., Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):689-93
• All: 32 reference(s)