Tg(SOD1*G86R)M3Jwg
Transgene Detail

Summary

• Symbol: Tg(SOD1*G86R)M3Jwg
• Name: transgene insertion M3, Jon W Gordon
• MGI ID: MGI:2183738
• Synonyms: M3, Tg(SOD1*G85R)M3Jwg, Tg(Sod1-G86R)M3Jwg
• Transgene: Tg(SOD1*G86R)M3Jwg Location: unknown
• Alliance: Tg(SOD1*G86R)M3Jwg page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(SOD1*G86R)M3Jwg expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Sod1 (MGI:98351)	Transgene codes for a protein with a glycine to arginine mutation.

• Mutation details: The entire mouse Sod1 gene with an engineered glycine to arginine mutation at residue 86 (G86R) of exon 4 was used as the transgene. Mutation G86R corresponds to the SOD1 G85R mutation found in some cases of human amyotrophic lateral sclerosis (ALS) patients. Founder M3 exhibited high transgene expression in the brain. (J:22628)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

The founder mouse was a female and proved unable to breed.

References

• Original: J:22628 Ripps ME, et al., Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):689-93
• All: 3 reference(s)