Tg(Pmp22)My41Clh
Transgene Detail

Summary

• Symbol: Tg(Pmp22)My41Clh
• Name: transgene insertion My41, Clare Huxley
• MGI ID: MGI:2183742
• Synonyms: My41
• Transgene: Tg(Pmp22)My41Clh Location: unknown
• Alliance: Tg(Pmp22)My41Clh page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/Ca)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pmp22)My41Clh expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pmp22 (MGI:97631)

• Mutation details: A 310 kb YAC containing the entire mouse Pmp22 gene and at least 60 kb and 90 kb of upstream and downstream sequences, respectively, was used as the transgene. Three lines were created (Jdelta42, My39 and My41) with My41 selected as the representative line as it is the only one with myelination defects. (J:76795)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Transgenic offspring of founder My41 developed unstable gait and progressive hind limb weakness by 3 weeks of age. Most animals were sacrificed at 5 months.

References

• Original: J:76795 Robertson AM, et al., Comparison of a new pmp22 transgenic mouse line with other mouse models and human patients with CMT1A. J Anat. 2002 Apr;200(4):377-90
• All: 1 reference(s)