Crabp2^tm1Ipc
Targeted Allele Detail

Summary

• Symbol: Crabp2^tm1Ipc
• Name: cellular retinoic acid binding protein II; targeted mutation 1, Pierre Chambon
• MGI ID: MGI:2183745
• Synonyms: CRABPII -
• Gene: Crabp2 Location: Chr3:87856000-87860679 bp, + strand Genetic Position: Chr3, 38.78 cM
• Alliance: Crabp2^tm1Ipc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:23139
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequences in exon 1 between nucleotides +119 and +164 were replaced with a neomycin selection cassette. The deleted sequences include the translation initiation site and the first 5 codons. RNase protection assays on E13.5 embryos demonstrated that an abnormal transcript was expressed from this allele, but no signal was detected in western blots in extracts derived from E13.5 homozygous embryos. (J:23139)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crabp2 Mutation: 30 strains or lines available

References

• Original: J:23139 Lampron C, et al., Mice deficient in cellular retinoic acid binding protein II (CRABPII) or in both CRABPI and CRABPII are essentially normal. Development. 1995 Feb;121(2):539-48
• All: 5 reference(s)