Tg(UcpDta)1Kz
Transgene Detail

Summary

• Symbol: Tg(UcpDta)1Kz
• Name: transgene insertion 1, Leslie P Kozak
• MGI ID: MGI:2183746
• Synonyms: BATless, UCP-DTA
• Transgene: Tg(UcpDta)1Kz Location: unknown
• Alliance: Tg(UcpDta)1Kz page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: Incorporation of a toxic transgene, diphtheria toxin-A-chain (Dta), coupled to regulatory elements of the gene for brown adipose tissue specific uncoupling protein (Ucp) resulted in the ablation of brown adipose tissue (BAT). Specifically, Dta was inserted into the first exon of Ucp1 at position +120 to create the vector. (J:78211)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:78211 Lowell BB, et al., Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature. 1993 Dec 23-30;366(6457):740-2
• All: 20 reference(s)