Ncoa2^tm1.2Ipc
Targeted Allele Detail

Summary

• Symbol: Ncoa2^tm1.2Ipc
• Name: nuclear receptor coactivator 2; targeted mutation 1.2, I Pierre Chambon
• MGI ID: MGI:2183803
• Synonyms: SRC-2^-, TIF-2-, TIF2-, TIF2^L-
• Gene: Ncoa2 Location: Chr1:13209329-13444307 bp, - strand Genetic Position: Chr1, 4.12 cM, cytoband A3-A5
• Alliance: Ncoa2^tm1.2Ipc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78075
• Parent Cell Line: H1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated by breeding mice carrying Ncoa2^tm1Ipc with transgenic mice expressing cre recombinase via the CMV promoter. The expression of cre resulted in the excision of the floxed region containing the neo transgene and the exon encoding the nuclear receptor interaction domain. Sequence analysis showed that a frameshift mutation begining at codon 375 introduced a stop codon at position 490. Immunohistochemical staining of homozygous mutant testes showed an absence of reactivity. (J:78075)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncoa2 Mutation: 76 strains or lines available

References

• Original: J:78075 Gehin M, et al., The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP. Mol Cell Biol. 2002 Aug;22(16):5923-37
• All: 24 reference(s)