Myoc^tm1.1Rjo
Targeted Allele Detail

Summary

• Symbol: Myoc^tm1.1Rjo
• Name: myocilin; targeted mutation 1.1, Randy L Johnson
• MGI ID: MGI:2183812
• Gene: Myoc Location: Chr1:162466724-162477262 bp, + strand Genetic Position: Chr1, 70.29 cM
• Alliance: Myoc^tm1.1Rjo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72628
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Intragenic deletion
• Mutation details: The mutant is derived from Myoc^tm1Rjo where the floxed neo cassette has been removed by crossing to a cre-expressing mouse line. The absence of gene expression in eyes of homozygous mutant animals was confirmed by Western blot analysis and RT-PCR. (J:72628)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myoc Mutation: 27 strains or lines available

References

• Original: J:72628 Kim BS, et al., Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of Function. Mol Cell Biol. 2001 Nov;21(22):7707-13
• All: 7 reference(s)