Tg(APOB)11Rub
Transgene Detail

Summary

• Symbol: Tg(APOB)11Rub
• Name: transgene insertion 11, Edward M Rubin
• MGI ID: MGI:2183814
• Synonyms: HuBTg
• Transgene: Tg(APOB)11Rub Location: unknown
• Alliance: Tg(APOB)11Rub page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOB)11Rub expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOB (338)

  Apob	(MGI:88052)

• Mutation details: The human APOB gene (~19 kb of genomic sequence 5' to the translational start site of the gene and ~14kb of genomic sequence 3' to the transcription termination site) was introduced into fertilized FVB mouse embryos. Multiple lines were generated, ranging in copy number from 1 to 11 for the human gene, by Southern blot. This transgene is the high-expressing line, with an estimated eleven copies of the APOB gene in liver of these mice. (J:78212)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:78212 Callow MJ, et al., Expression of human apolipoprotein B and assembly of lipoprotein(a) in transgenic mice. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2130-4
• All: 18 reference(s)