Acta1^tm1Jll
Targeted Allele Detail

Summary

• Symbol: Acta1^tm1Jll
• Name: actin alpha 1, skeletal muscle; targeted mutation 1, James L Lessard
• MGI ID: MGI:2183817
• Gene: Acta1 Location: Chr8:124618508-124621490 bp, - strand Genetic Position: Chr8, 72.26 cM
• Alliance: Acta1^tm1Jll page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78070
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by the insertion of an hprt minigene. Northern blot analysis of total RNA obtained from limbs showed an absence of transcript in homozygous mutant mice. (J:78070)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acta1 Mutation: 16 strains or lines available

References

• Original: J:78070 Crawford K, et al., Mice lacking skeletal muscle actin show reduced muscle strength and growth deficits and die during the neonatal period. Mol Cell Biol. 2002 Aug;22(16):5887-96
• All: 4 reference(s)